Pharmacophore an International Research Journal
The use of sorbents helps to reduce the toxic load when toxic chemicals and radionuclides enter the body. This article investigates the pharmacological properties of the new ferrocyanide-bentonite sorbent Ferbensorb. Ferbensorb is a composite sorbent containing potassium-iron(III) hexacyanoferrate(II), as well as bentonite, gelatin, and macro- and microelements. The article presents the results of experimental studies conducted on laboratory animals (rats and mice). Sorption activity with the introduction of cesium, sorption capacity with the introduction of strontium radionuclides, and sorption capacity with experimental associative mycotoxicosis were determined. In addition, a pathoanatomical autopsy was performed, and changes in body weight and some internal organs of the studied animals were determined, as well as the leukocyte formula. It was found that ferrocyanide-bentonite sorbent Ferbensorb significantly reduced the functional and morphological manifestations of the pathological process caused by mycotoxins ochratoxin A, fumonisin B, and zearalenone. It increased body weight gain, indicators of natural immunological resistance, which was expressed by an increase in the percentage of neutrophils in the leukoformula, an increase in the level of bactericidal and lysozyme activity of blood serum, and animal survival.
