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Open Access | Published: 2024 - Issue 2

The Quick Method for Obtaining Microcapsules with Magnolia officinalis Oil Included and Its Application in the Medical Field Download PDF


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  1. Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410087, Oradea, Romania.
  2. Department of Pharmacy, University of Medicine and Pharmacy, Science and Technology of Targu Mures, Targu Mures, 540142, Romania.
  3.   Department of Environmental Engineering, Faculty of Environmental Protection, University of Oradea, 410048 Oradea, Romania

     

  4. Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.

  5. Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410081 Oradea, Romania.
  6. Department of Genetic Engineering, University of Life Sciences "King Mihai I" Timișoara, Timișoara, Romania.
Abstract

Magnolia officinalis is a tree whose parts (bark, leaves, flowers) are characterized by a content-rich in phytochemical compounds of great interest nowadays. Modern medicine relies on the replacement of conventional treatments or the completion of treatment schemes with plant extracts rich in different phytochemical classes for greater efficiency and to reduce side effects. In this work, the oil was extracted from the leaves of Magnolia officinalis, which was characterized by GC-MS, highlighting the majority of compounds from the class of monoterpenes (linalool and linalool derivatives) and sesquiterpenes (caryophyllene). These compounds have been described from the point of view of the action they can exert in different conditions, highlighting the main mechanisms of action. Magnolia officinalis leaves were also characterized by macro- and microscopic analysis. The obtained oil was tested from the point of view of antimicrobial activity on gram-positive and gram-negative bacteria and was included in biocompatible capsules through a quick and cheap method called the coacervation method. The need to encapsulate the oil is given by the fact that the properties of Magnolia oil are lost over time if it is preserved as such and due to the low bioavailability in the case of oral administration, the encapsulated form solves all these inconveniences. Future perspectives are related to testing the bioavailability of the encapsulated Magnolia oil by oral administration of the capsules and testing their properties over time during storage.

Cite this article
Vancouver
Ganea M, Horvath T, Nagy C, Morna AA, Pasc P, Szilagyi A, et al. The Quick Method for Obtaining Microcapsules with Magnolia officinalis Oil Included and Its Application in the Medical Field. Pharmacophore. 2024;15(2):16-24. https://doi.org/10.51847/83Wyrb1MCv
APA
Ganea, M., Horvath, T., Nagy, C., Morna, A. A., Pasc, P., Szilagyi, A., Szilagyi, G., Sarac, I., & Cote, A. (2024). The Quick Method for Obtaining Microcapsules with Magnolia officinalis Oil Included and Its Application in the Medical Field. Pharmacophore, 15(2), 16-24. https://doi.org/10.51847/83Wyrb1MCv

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