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Open Access | Published: 2024 - Issue 4

Evaluation of Cytotoxic and Cytostatic Activity of Chlorophytum comosum Methanol Extract Download PDF


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  1. Department of Therapy, Faculty of Medicine of Stavropol State Medical University, Stavropol, Russia

  2. Department of Therapy, Faculty of Pediatrics of Stavropol State Medical University, Stavropol, Russia

  3. Department of Therapy, Faculty of Medicine, North Ossetian State Medical Academy, Vladikavkaz, Republic of North Ossetia-Alania, Russia

  4. Department of Therapy, Faculty of Dentistry, Private Educational organization of Higher Professional Education "Reaviz Medical University", Moscow, Russia

Abstract

Chlorophytum comosum leaf extract is well-known to contain flavonoids. The extract has cytotoxic and cytostatic activity in normal animal cells. At concentrations of 15 mg/mL and above, the extract leads to 100% death of SPEV cells. The number of dead cells of the SPEV line generally increases with increasing extract concentration. The LC50 of Chlorophytum comosum extract was determined by probit analysis (LC50 = 7.24 mg/mL). With an increase in the concentration of the extract, a noticeable decrease in the proliferative activity of cells was observed. After 48 hours, the inhibition of proliferative activity of SPEV cells is more pronounced than after 24 hours. The percentage of SPEV cells that died under the action of Chlorophytum comosum extract becomes smaller with increasing exposure time.  The results of the analysis of the tumor mass at the end of the experiment fully correspond to the dynamics of its growth. The data obtained by us indicate the absence of the effect of Chlorophytum comosum extract against the transferable liver cancer of rats in an in vivo experiment.

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Vancouver
Turabov ME, Kolesnikova VV, Bazaeva AR, Dzukheraeva DB, Ternovoy VV, Kompaneec AD, et al. Evaluation of Cytotoxic and Cytostatic Activity of Chlorophytum comosum Methanol Extract. Pharmacophore. 2024;15(4):33-8. https://doi.org/10.51847/D5CauwttEJ
APA
Turabov, M. E., Kolesnikova, V. V., Bazaeva, A. R., Dzukheraeva, D. B., Ternovoy, V. V., Kompaneec, A. D., Zhiteneva, V. A., & Medvedeva, V. A. (2024). Evaluation of Cytotoxic and Cytostatic Activity of Chlorophytum comosum Methanol Extract. Pharmacophore, 15(4), 33-38. https://doi.org/10.51847/D5CauwttEJ

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