Pharmacophore an International Research Journal
Pharmacophore
Submit Manuscript
Open Access | Published: 2024 - Issue 3

Phаrmacological Activity of Metal-Based Organic Complexes Against Different Viral Diseases Download PDF


, ,
  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, Sofia 1000, Bulgaria.
  2. Vascular Surgery Clinic, Military Medical Academy, Sofia1606, Bulgaria.
  3. Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Sofia 1000, Bulgaria.
Abstract

The necessity of the development of compounds with effectiveness in therapy against infective diseases has increased in the last 3 years in connection with the spread of COVID-19. The current study aimed to summarize the pharmacological activities of metal-based organic compounds against different viral diseases, including COVID-19. A systematic literature review was carried out by using data sources in Medline, Pub Med, SCOPUS, and Science Direct. The used methods were collecting data, summarizing, and analyzing information. Antiviral properties exert metal complexes with ligands, such as: hydrazones; thiosemi-carbazones: Pt(II), Pd(II); Ga(III); Pd(II); Co(III), Ni(II), Cu(II)); fluoroquinolones, quinoline: Pd(II); phenylquinoline, phenylpyridine; tetrahydropyrimidines: Ag(I); phenanthroline: Cu(II); Valacyclovir: Cu(II)). Complexes of Zn(II). Co(II), Cu(II), Ni(II), Mg(II), Mn(II), and Zn(II) exert antiviral effects against the DNA Herpes simplex viruses HSV-1, HSV-2. Co(II), effective towards the HIV are complexes of the following metals: Au(II), Co(II), Cu(II), Fe(III), La(III), Mg(II). Ni(II), Pd(II), Pt(II), Ru(II). Against the HIV have been described to be active complexes of the following metals: Au(II), Co(II), Cu(II), Fe(III), La(III), Mg(II), Ni(II), Pd(II), Pt(II), and Ru(II). In connection with the continued spread of the severe acute respiratory syndrome – Coronavirus 2 (SARS-CoV-2), today's very actual strategy is the development of effective COVID therapeutics. The perspective trend in the creation and investigation of potential agents for the effective application towards SARS-CoV-2, are Auranofin and Cu(II), Ni(II), Mn(II), and Zn(II) complexes of Coumarin.

Cite this article
Vancouver
Tsvetkova DD, Marangozov SD, Kostadinova II. Phаrmacological Activity of Metal-Based Organic Complexes Against Different Viral Diseases. Pharmacophore. 2024;15(3):1-11. https://doi.org/10.51847/ITDUlEZZj3
APA
Tsvetkova, D. D., Marangozov, S. D., & Kostadinova, I. I. (2024). Phаrmacological Activity of Metal-Based Organic Complexes Against Different Viral Diseases. Pharmacophore, 15(3), 1-11. https://doi.org/10.51847/ITDUlEZZj3

Related articles:
Most viewed articles:
QR code:

Short Link:
Views: 264

Downloads: 45
Quick Access

Pharmacophore
ISSN: 2229-5402

Copyright © 2024 Pharmacophore
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.